英语翻译Tuberculosis Prevention in Mexican ImmigrantsLimitations

英语翻译
Tuberculosis Prevention in Mexican ImmigrantsLimitations of Short-Course Therapy
Namratha R.Kandula,MD,MPH,Mark S.Dworkin,MD,MHTPM,Margaret R.Carroll,RN,BS,Diane S.Lauderdale,PhD
Background:Two months of rifampin and pyrazinamide (RIF/PZA) for tuberculosis prevention ha been advocated as a way to improve adherence in mobile populations,such as recen immigrants.However,RIF/PZA requires intensive patient and laboratory monitoring for hepatotoxicity.
Objectives:To describe the feasibility and outcomes of using RIF/PZA for TB prevention during a tuberculosis outbreak in a Mexican immigrant community,where 23 adults and 11 children were treated with RIF/PZA between August 2001 and October 2001.
Methods:Retrospective chart review and interviews with health department employees were conducted to assess completion rates,hepatotoxicity,cost,and feasibility of monitoring.
Results:Ten (91%) children and 13 (57%) adults completed RIF/PZA.One child (9%) and four adults (17%) developed drug-induced hepatitis.Cultural barriers affected care.The adult resisted the biweekly blood draw,believing it would “drain them of energy.” RIF/PZA,plumonitoring,was twice as costly as 4 months of rifampin.
Conclusions:RIF/PZA was associated with significant hepatotoxicity,poor completion,and cultura barriers to monitoring,and was more costly than standard therapy.Tuberculosis prevention must address potential clinical,cultural,and economic barriers to completion and monitoring of short-course therapy in immigrants.
(Am J Prev Med 2004;26(2):163–166) © 2004 American Journal of Preventive Medicine

翻译：
Tuberculosis Prevention in Mexican ImmigrantsLimitations of Short-Course Therapy
墨西哥移民结核病防治的短期疗法的局限性
Namratha R.Kandula,MD,MPH,Mark S.Dworkin,MD,MHTPM,Margaret R.Carroll,RN,BS,Diane S.Lauderdale,PhD
这些是作者名字,不翻译了,自己音译吧
Background:Two months of rifampin and pyrazinamide (RIF/PZA) for tuberculosis prevention ha been advocated as a way to improve adherence in mobile populations,such as recen immigrants.However,RIF/PZA requires intensive patient and laboratory monitoring for hepatotoxicity.
背景：使用为期2个月的利福平和吡嗪酰胺 (RIF/PZA)作为结核病的防治方法已经被当成一种提高流动人口（比如移民）的凝聚力的方式.然而 RIF/PZA要求病人要相对集中和对肝脏毒性的实验室观察.
Objectives:To describe the feasibility and outcomes of using RIF/PZA for TB prevention during a tuberculosis outbreak in a Mexican immigrant community,where 23 adults and 11 children were treated with RIF/PZA between August 2001 and October 2001.
目的：为了阐述在墨西哥移民社区结核病爆发期间使用RIF/PZA作为结核病防治措施的可行性与效果,从2001年8月至10月,这个社区的23名成年人和11名小孩接受了RIF/PZA 治疗.
Methods:Retrospective chart review and interviews with health department employees were conducted to assess completion rates,hepatotoxicity,cost,and feasibility of monitoring.
方法：以审核可回顾图表和对卫生部雇员的访问作为对完成率、肝脏毒性、费用和观察的可行性的评价方式.
Results:Ten (91%) children and 13 (57%) adults completed RIF/PZA.One child (9%) and four adults (17%) developed drug-induced hepatitis.Cultural barriers affected care.The adult resisted the biweekly blood draw,believing it would “drain them of energy.” RIF/PZA,plumonitoring,was twice as costly as 4 months of rifampin.
结果：10个儿童（91%）和13个成人（57%）完成了RIF/PZA,一个儿童（9%）和4个成人（17%）产生了药物性肝炎.文化障碍影响到了治疗效果.成年人抵触2个星期一次的血液抽查,因为他们认为这会“吸干他们的活力”.在无监察的情况下,使用RIF/PZA的费用相当于利福平4个月用药的费用.
Conclusions:RIF/PZA was associated with significant hepatotoxicity,poor completion,and cultura barriers to monitoring,and was more costly than standard therapy.Tuberculosis prevention must address potential clinical,cultural,and economic barriers to completion and monitoring of short-course therapy in immigrants.
结论：RIF/PZA具有显著的肝脏毒性,低治疗性,受文化障碍的影响而难以监察,并且比标准的治疗方法费用更高.结核病防治应致力于可行的临床的、无文化障碍和更经济的方式来实现对移民们短期治疗的监察与效果.
(Am J Prev Med 2004;26(2):163–166) © 2004 American Journal of Preventive Medicine
美国预防医学杂志(Am J Prev Med 2004;26(2):163–166) © 2004
不是专业的,请参考!