in all,at all,after all和first of all的区别及意义

意思完全不同的

after all
毕竟, 终究, 归根结底
1. you should forgive him for his forgetfulness; after all, he is over seventy.
你应该原谅他的健忘症，毕竟他已经七十多岁了。

2. you should be charitable with him; he is a child after all.
你应该对他宽容些，毕竟他还是个孩子。

3. i was so tired after all that gardening that i was out for the count for ten whole hours last night.
把花园里所有的活干完后，我实在太累了，昨晚沉睡了足足有10个小时。 

at all
完全, 全然; 究竟; 竟然; 在任何程度上
1. i don't think that's a bad idea at all.
我看这完全不是个坏主意。

2. it doesn't matter at all.
这根本没什么关系。

3. he is not at all alive to the danger he is in.
他完全没有意识到他处境的危险。

at first
首先, 最初
1. we didn't trust him at first, but his charming manner completely disarmed us.
我们开始时并不信任他，但他令人愉快的举止完全消除了我们的疑虑。
dict.cn 
2. at first he refused to accept any responsibility but he ended up apologizing.
最初他拒不承认有任何责任, 到头来还是道了歉.

3. at first we used hand tools.
首先我们使用手工工具。

first of all
首先
1. marriage is, first of all, a contract which must be governed by justice.
婚姻首先是一种契约，它必须以公正为制约。

2. first of all, we are today as senator kennedy has admitted, the strongest nation in the world militarily.
首先，正如肯尼迪参议员所承认的那样，我们是世界头号大国

3. first of all, let me tell you the news.
首先，让我告诉你这个消息。