跪求文章名为：Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin 的全文中文翻译

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干细胞大有希望再生医学，但仍然难以实现，在许多组织，因为缺乏足够的最终标志。进展小鼠遗传学提供了工具，表征和验证的干细胞标记的功能和/或谱系追踪实验。分子靶基因Lgr 5最近已确定为一种新的干细胞标记的肠上皮细胞和毛囊。在小肠，Lgr 5表示完全是在自行车隐窝基地的柱状细胞。遗传谱系追踪实验表明，隐窝基地的柱状细胞能够自我更新和多能，从而代表真正的肠道干细胞。在干细胞小生境的小鼠毛囊，Lgr 5表达的是积极的循环细胞。移植和谱系追踪实验表明，这些Lgr 5（+E）保持细胞的所有的细胞谱系的毛囊在很长一段时间，可以建立整个新毛囊。表达LGR 5在多个其他机关表明，它可能是一个全球性的标志成人干细胞。本次审查试图提供全面概述了干细胞舱室的肠道和皮肤为重点的循环，然而，长寿命和多，Lgr 5（+E）干细胞的人口。（美国病理学杂志2009，174.715-721；内政部。10.2353 /2009.080758ajpath。）

Stem cells hold great promise for regenerative medicine, but have remained elusive In many tissues because of a lack of adequate definitive markers. Progress in mouse genetics has provided the tools for characterization and validation of stem cell markers by functional and/or lineage tracing assays. The Wnt target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium and the hair follicle. In the intestine, Lgr5 Is exclusively expressed in cycling crypt base columnar cells. Genetic lineage-tracing experiments revealed that crypt base columnar cells are capable of self-renewal and multipotency, thus representing genuine intestinal stem cells. in the stem cell niche of the murine hair follicle, Lgr5 is expressed in actively cycling cells. Transplantation and lineage tracing experiments have demonstrated that these Lgr5(+ve) cells maintain all cell lineages of the hair follicle throughout long periods of time and can build entire new hair follicles. Expression of Lgr5 in multiple other organs indicates that it may represent a global marker of adult stem cells. This review attempts to provide a comprehensive overview of the stem cell compartments In the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations. (Am J Pathol 2009, 174.715-721; DOI. 10.2353/ajpath.2009.080758)

信号，Lgr 5，和干细胞在肠道和皮肤

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