-- Alison, I’m sorry. I can’t come to the wedding with you tomorrow morning. ?-- My gra

-- Alison, I’m sorry. I can’t come to the wedding with you tomorrow morning. -- ?
-- My grandma was severely ill, so I have to stay in the hospital to look after her.
A. How is it
B. How come
C. So what
D. What’s the problem

A. How is it(答案→)B. How comeC. So whatD. What’s the problem解析：考查交际用语。How is it它好吗？How come为何会呢？So what那又怎么样？What’s the problem问题怎么了，句意：艾丽斯，很抱歉，明天早晨我不能和你一起去参加婚礼了。为何会呢？我的奶奶病的很严重，因此我不得不呆在医院照顾她。所以选B。

好好学习下